![]() Residue removal is accomplished during CIP with a combination of heat, chemical action, and turbulent flow. It is used to remove in-process residues, control bioburden, and reduce endotoxin levels within processing equipment and systems. CIP is performed to remove or obliterate previous mammalian cell culture batch components. This process cleans the borehole interior and equipment without any invasive maintenance being required.ĬIP is commonly used for cleaning bioreactors, fermenters, mix vessels, and other equipment used in biotech manufacturing, pharmaceutical manufacturing and food and beverage manufacturing. In addition, CIP systems can be built into the borehole headworks to permit the injection of cleaning solutions (such as sodium hypochlorite or other sanitizers) and the subsequent recirculation of the mix of these chemicals and the groundwater. An air filter is built into the headworks to permit the borehole to inhale and exhale when the water level rises and falls quickly (usually due to the pump being turned on and off) without drawing in airborne particles or contaminants (spores, molds, fungi, bacteria, etc.). Originally developed for cleaning closed systems as described above, CIP has more recently been applied to groundwater source boreholes used for high end-uses such as natural mineral/spring waters, food production and carbonated soft drinks (CSD).īoreholes that are open to the atmosphere are prone to a number of chemical and microbiological problems, so sources for high end-use are often sealed at the surface ( headworks). The turbulence creates an abrasive force that dislodges stubborn soil from the dirty surface. Pressure exerted by the cleaning solution (or turbulence). After some time, the detergent eventually dissolves the hard stains/soil from the dirty surface. The longer the detergent contact period, the higher the cleaning efficiency. A concentrated cleaning solution will clean a dirty surface much better than a dilute one due to the increased surface binding capacity.Ĭontact time of the cleaning solution. Molecules with high kinetic energy dislodge dirt faster than the slow moving molecules of a cold solution.Ĭoncentration of the cleaning agent. Elevating the temperature of a cleaning solution increases its dirt removal efficiency. Įlevated temperature and chemical detergents are often employed to enhance cleaning effectiveness.įactors affecting the effectiveness of the cleaning agents
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